Fingerprinting Ikaros

Ikaros regulates neutrophil differentiation.

The Ikaros gene encodes a zinc finger transcription factor that is selectively expressed by all hematopoietic cells. Although Ikaros is required for lymphocyte differentiation, its role in the myeloid lineage is unclear. We show here that Ikaros expression is temporally regulated during neutrophil differentiation: Ikaros is primarily expressed at immature stages and significantly less so in mat...

Ikaros in T-Cell Leukemia

Although extensive clinical data have established that the loss of Ikaros tumor suppressor activity via genetic inactivation is a major contributor to leukemogenesis leading to B-cell ALL, less is known about the role of Ikaros in T-cell leukemia. The T-cell malignancies observed in Ikaros-deficient mice suggest that Ikaros is likely to function as a tumor suppressor in T-cells. In human, multi...

The Role of Ikaros in Human Erythroid Differentiation. Short Title : Ikaros and human erythroid differentiation

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.

The Ikaros gene encodes multiple protein isoforms that contribute critical functions during the development of lymphocytes and other hematopoietic cell types. The intracellular functions of Ikaros are not known, although recent studies have shown that Ikaros proteins colocalize with inactive genes and centromeric heterochromatin. In this study, Ikaros proteins were found to be components of hig...

System-Level Cognitive Modeling with Ikaros

The Ikaros project started in 2001 with the aim at developing an open infrastructure for system-level brain modeling. The system has developed into a general tool for cognitive modeling as well as robot control. This report describes the main parts of the Ikaros system, in particular the simulation kernel, and summarizes the work done within the first five years of the project.